Protein Details: Voltage-gated sodium channel subunit beta-1

Protein ID

ICDB_Pro_0051

Protein Name

Voltage-gated sodium channel subunit beta-1

Gene Name

SCN1B

Organism

Pan troglodytes (Chimpanzee)

Length

218 amino acids

AlphaFoldDB

AF-A5A6L6-F1-model_v4.pdb

Function

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain; heart and skeletal muscle. Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation. Modulates the activity of a variety of pore-forming alpha subunits; such as SCN1A; SCN2A; SCN3A; SCN4A; SCN5A and SCN10A.

Sequence

MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain; heart and skeletal muscle

DOI ID

10.1016/j.gene.2007.04.013

RefSeq

NP_001104291.1